1 min read

ID: 1091206

Short Link: https://gregory-ms.com/articles/1091206/

Discovery Date: 13 November 2022, 00:15:51 UTC

Published Date: 2022-11-04 00:00:00

Source: MS & Rel. Disorders

Link: https://www.msard-journal.com/article/S2211-0348(22)00901-4/fulltext

Manual Selection: none

Machine Learning Gaussian Naive Bayes Model: true

Abstract

Background

The presence of lipid-specific oligoclonal IgM bands (LS-OCMB) in cerebrospinal fluid is associated with a more severe clinical multiple sclerosis (MS) course. Objective To investigate LS-OCMB as a prognostic biomarker of cognitive long-term outcomes in MS.

Methods

Ninety-nine patients underwent neuropsychological assessment. Cognitive performance between LS-OCMB– and LS-OCMB+ patients was compared adjusting by age, education, anxiety-depression, disease duration, and disability.

Results

LS-OCMB+ patients of ∼13 years of disease duration performed worse on Symbol Digit Modalities Test (SDMT) (p = 0.005).

Conclusion

LS-OCMB+ perform worse on information processing speed and working memory (SDMT), suggesting that LS-OCMB could be a useful biomarker for long-term cognitive outcomes.

Noun Phrases in Title

  • Oligoclonal IgM bands
  • a promising biomarker
  • long-term cognitive outcomes
  • multiple sclerosis
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