2 min read

ID: 1108558

Short Link: https://gregory-ms.com/articles/1108558/

Discovery Date: 24 November 2022, 18:20:33 UTC

Published Date: 2022-11-24 11:00:00

Source: PubMed

Link: https://pubmed.ncbi.nlm.nih.gov/36421810/?fc=20210216052009&ff=20221124132014&v=2.17.8

Manual Selection: none

Machine Learning Gaussian Naive Bayes Model: false


Genes (Basel). 2022 Nov 17;13(11):2136. doi: 10.3390/genes13112136.


Multiple sclerosis (MS) is a complex disease of the central nervous system for which human leukocyte antigen (HLA) alleles are major contributors to susceptibility. Several investigations have focused on the relationship between HLA and clinical parameters, while few studies have evaluated its correlation with brain magnetic resonance imaging (MRI) measures. We investigated the association between the HLA genetic burden (HLAGB), originating from the most updated HLA alleles associated with MS, and neuroimaging endophenotypes, with a specific focus on brain atrophy metrics. A monocentric Italian cohort of 334 MS patients with imputed HLA alleles and cross-sectional volumetric measures of white matter (WM), gray matter (GM), hippocampus, thalamus and T2-hyperintense lesions was investigated. Linear regression models with covariate adjustment were fitted for each metric. We detected no effect of HLAGB on WM and GM volumes. Interestingly, we found a marginal correlation between higher HLAGB and lower hippocampal volume (β = -0.142, p = 0.063) and a nominal association between higher HLAGB and lower thalamic volume (β = -0.299, p = 0.047). No association was found with T2 lesion volumes. The putative impact of higher HLAGB on hippocampus and thalamus suggests, if replicated in independent cohorts, a possible cumulative contribution of HLA risk loci on brain volumetric traits linked to clinical deficits in MS.

PMID:36421810 | DOI:10.3390/genes13112136

Noun Phrases in Title

  • the Association
  • HLA Genetic Risk Burden
  • Thalamic and Hippocampal Atrophy
  • Multiple Sclerosis Patients
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