1 min read

ID: 1108560

Short Link: https://gregory-ms.com/articles/1108560/

Discovery Date: 24 November 2022, 18:20:44 UTC

Published Date: 2022-11-24 11:00:00

Source: PubMed

Link: https://pubmed.ncbi.nlm.nih.gov/36421672/?fc=20210216052009&ff=20221124132014&v=2.17.8

Manual Selection: true

Machine Learning Gaussian Naive Bayes Model: false

Abstract

Curr Issues Mol Biol. 2022 Nov 18;44(11):5728-5740. doi: 10.3390/cimb44110388.

ABSTRACT

Multiple Sclerosis (MS) is a demyelinating autoimmune disorder of the central nervous system (CNS). Experimental autoimmune encephalomyelitis (EAE) has been widely used to determine the pathogenesis of the disease and evaluate new treatment strategies for MS. Therefore, we investigated the efficacy of oral administration of a Myelin Oligodendrocyte Glycoprotein (MOG) in the treatment of EAE. Female C57BL/6 mice were utilized in three groups (Control group, received PBS orally; prevention group, oral administration of MOG35-55 two weeks before EAE induction; treatment group, oral administration of MOG35-55 after EAE induction). MOG administration, both as prevention and treatment, significantly controlled clinical score, weight loss, CNS inflammation, and demyelination, mainly through the modulation of T cell proliferation, and reduction in pro-inflammatory cytokines and transcription factors, including TNF-α, IFN-γ, IL-17, T-bet, and ROR-γt. MOG administration, both as prevention and treatment, also induced anti-inflammatory cytokines and transcription factors, including IL-4, TGF-β, GATA-3, and Foxp3. The results showed that oral administration of MOG, both as prevention and treatment, could efficiently control EAE development. Immunomodulatory mechanisms include the induction of Th2 and Treg cells and the suppression of pro-inflammatory Th1 and Th17 cells.

PMID:36421672 | DOI:10.3390/cimb44110388

Noun Phrases in Title

  • Oral Administration
  • Myelin Oligodendrocyte Glycoprotein
  • Induction
  • Th2/Treg Cells
  • Suppression
  • Th1/Th17 Immune Responses
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