1 min read

ID: 21

Short Link: https://gregory-ms.com/articles/21/

Discovery Date: 23 February 2021, 11:11:00 UTC

Published Date: 2021-01-04 00:00:00

Source: PubMed

Link: https://pubmed.ncbi.nlm.nih.gov/33610019/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&fc=20210216052009&ff=20210221121510&v=2.1

Manual Selection: none

Machine Learning Gaussian Naive Bayes Model: false


Stem Cell Res. 2021 Feb 12;52:102246. doi: 10.1016/j.scr.2021.102246. Online ahead of print.


Amyotrophic lateral sclerosis (ALS) is characterized by degeneration of upper and lower motor neurons, causing gradual paralysis, and resulting in death 3-5 years from diagnosis. ALS causative mutations have been identified in multiple genes, including Fused in sarcoma (FUS), and recently characterized Annexin A11 (ANXA11). We have derived induced pluripotent stem cell (iPSC) lines from six ALS patient lymphoblastoid cell lines, three with mutations in FUS (Q519E, R521H, R522G), and three with mutations in ANXA11 (G38R, D40G, R235Q). These lines have been characterized and provide a novel resource for investigation into ALS pathology.

PMID:33610019 | DOI:10.1016/j.scr.2021.102246

Noun Phrases in Title

  • Generation
  • six induced pluripotent stem cell lines
  • patients
  • amyotrophic lateral sclerosis
  • associated genetic mutations
  • either FUS
  • ANXA11
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