1 min read

ID: 288841

Discovery Date: 14 May 2022, 13:10:06 UTC

Published Date: 2022-05-14 10:00:00

Source: PubMed

Link: https://pubmed.ncbi.nlm.nih.gov/35563467/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&fc=20210216052009&ff=20220514091005&v=2.17.6

Manual Selection: none

Machine Learning Gaussian Naive Bayes Model: false

Abstract

Complex asparagine-linked glycosylation plays key roles in cellular functions, including cellular signaling, protein stability, and immune response. Previously, we characterized the appearance of a complex asparagine-linked glycosylated form of lysosome-associated membrane protein 1 (LAMP1) in the cerebellum of Npc1^(-/-) mice. This LAMP1 form was found on activated microglia, and its appearance correlated both spatially and temporally with cerebellar Purkinje neuron loss. To test the importance…

Noun Phrases in Title

  • Complex N-Linked Glycosylation
  • A Potential Modifier
  • Niemann-Pick Disease
  • Type C1 Pathology
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