1 min read

ID: 51

Short Link: https://gregory-ms.com/articles/51/

Discovery Date: 23 February 2021, 11:11:00 UTC

Published Date: 2021-02-22 00:00:00

Source: PubMed

Link: https://pubmed.ncbi.nlm.nih.gov/33617447/?utm_source=Chrome&utm_medium=rss&utm_campaign=pubmed-2&utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&fc=20210216052009&ff=20210223163220&v=2.

Manual Selection: none

Machine Learning Gaussian Naive Bayes Model: false

Abstract

Elife. 2021 Feb 22;10:e57417. doi: 10.7554/eLife.57417.

ABSTRACT

Cells exist within complex milieus of communicating factors, such as cytokines, that combine to generate context-specific responses, yet nearly all knowledge about the function of each cytokine and the signaling propagated downstream of their recognition is based on the response to individual cytokines. Here, we found that regulatory T cells (Tregs) integrate concurrent signaling initiated by IL-2 and IL-4 to generate a response divergent from the sum of the two pathways in isolation. IL-4 stimulation of STAT6 phosphorylation was blocked by IL-2, while IL-2 and IL-4 synergized to enhance STAT5 phosphorylation, IL-10 production, and the selective proliferation of IL-10-producing Tregs, leading to increased inhibition of conventional T cell activation and the reversal of asthma and multiple sclerosis in mice. These data define a mechanism of combinatorial cytokine signaling and lay the foundation upon which to better understand the origins of cytokine pleiotropy while informing improved the clinical use of cytokines.

PMID:33617447 | DOI:10.7554/eLife.57417

Noun Phrases in Title

  • IL-2
  • divergent regulatory T cell responses
  • therapeutic efficacy
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