1 min read

ID: 683533

Short Link: https://gregory-ms.com/articles/683533/

Discovery Date: 13 July 2022, 19:28:57 UTC

Published Date: 2022-07-12 23:00:00

Source: BioMedCentral

Link: https://stemcellres.biomedcentral.com/articles/10.1186/s13287-022-02963-4

Manual Selection: true

Machine Learning Gaussian Naive Bayes Model: false

Abstract

jats:titleAbstract</jats:title>jats:sec jats:titleBackground</jats:title> jats:pSpinal cord ischemia reperfusion injury (SCIRI) is a complication of aortic aneurysm repair or spinal cord surgery that is associated with permanent neurological deficits. Mesenchymal stem cell (MSC)-derived small extracellular vesicles (sEVs) have been shown to be potential therapeutic options for improving motor functions after SCIRI. Due to their easy access and multi-directional differentiation potential, adipose‐derived stem cells (ADSCs) are preferable for this application. However, the effects of ADSC-derived sEVs (ADSC-sEVs) on SCIRI have not been reported.</jats:p> </jats:sec>jats:sec jats:titleResults</jats:title> jats:pWe found that ADSC-sEVs inhibited SCIRI-induced neuronal apoptosis, degradation of tight junction proteins and suppressed endoplasmic reticulum (ER) stress. However, in the presence of the ER stress inducer, tunicamycin, its anti-apoptotic and blood–spinal cord barrier (BSCB) protective effects were significantly reversed. We found that ADSC-sEVs contain tumor necrosis factor (TNF)-stimulated gene-6 (TSG-6) whose overexpression inhibited ER stress in vivo by modulating the PI3K/AKT pathway.</jats:p> </jats:sec>jats:sec jats:titleConclusions</jats:title> jats:pADSC-sEVs inhibit neuronal apoptosis and BSCB disruption in SCIRI by transmitting TSG-6, which suppresses ER stress by modulating the PI3K/AKT pathway.</jats:p> </jats:sec>

Noun Phrases in Title

  • TSG-6
  • adipose stem cells-derived small extracellular vesicle protects
  • spinal cord ischemia reperfusion injury
  • endoplasmic reticulum stress
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