1 min read

ID: 6955

Discovery Date: 24 January 2022, 06:07:18 UTC

Published Date: 2022-01-23T11:00:00.000Z

Source: PubMed

Link: https://pubmed.ncbi.nlm.nih.gov/35066270/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&fc=20210216052009&ff=20220124010717&v=2.1

Manual Selection: none

Machine Learning Gaussian Naive Bayes Model: false


Mult Scler Relat Disord. 2022 Jan 15;58:103530. doi: 10.1016/j.msard.2022.103530. Online ahead of print.


BACKGROUND: In recent years, there has been an increasing interest in the central vein sign (CVS) as a new imaging marker and previous cross-sectional studies demonstrated that the CVS has the potential to discriminate multiple sclerosis (MS) lesions from non-MS lesions. The aim of this study was to investigate the consistency of the CVS in a longitudinal magnetic resonance imaging (MRI) data set.

METHODS: 3T MRI datasets from seventy-one people with MS acquired at baseline and after 12 months-follow-up were analyzed. Chronic lesions were identified on fluid-attenuated inversion recovery (FLAIR) images. Co-registered susceptibility-weighted/FLAIR images were analyzed for the presence of a CVS at baseline and follow-up.

RESULTS: A total of 183 chronic lesions were included in the final analysis. At baseline MRI, a CVS was detectable in 141/183 (77%) lesions. Overall, the CVS was consistent in 114/141 (81%) lesions (Cohen's kappa = 0.46, standard error = 0.07).

CONCLUSION: The CVS is a rather stable feature in chronic MS lesions and therefore represents a robust imaging marker that could increase the specificity of MRI in MS.

PMID:35066270 | DOI:10.1016/j.msard.2022.103530

Noun Phrases in Title

  • Consistency
  • the "central vein

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