1 min read

ID: 751509

Short Link: https://gregory-ms.com/articles/751509/

Discovery Date: 23 July 2022, 13:40:05 UTC

Published Date: 2022-07-22 10:00:00

Source: PubMed

Link: https://pubmed.ncbi.nlm.nih.gov/35868215/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&fc=20210216052009&ff=20220723094004&v=2.17.7

Manual Selection: true

Machine Learning Gaussian Naive Bayes Model: false


Multiple sclerosis (MS), an immune-mediated and neurodegenerative disorder of the central nervous system (CNS), is characterized by infiltrating myelin-reactive T lymphocytes and demyelinating lesions. Experimental autoimmune encephalomyelitis (EAE) is a well-established animal model used to study MS. To explore the impact of chemokine receptor CCR1 blockade in EAE and the underlying mechanisms, we used CCR1 antagonist J-113863 in PLP(139-151)-induced EAE in SJL/J mice. Following EAE induction,…

Noun Phrases in Title

  • CCR1
  • J-113863 corrects
  • the imbalance
  • pro-
  • anti-inflammatory cytokines
  • a SJL/J mouse model
  • relapsing-remitting multiple sclerosis
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