1 min read

ID: 769418

Short Link: https://gregory-ms.com/articles/769418/

Discovery Date: 25 July 2022, 23:40:06 UTC

Published Date: 2022-07-25 10:00:00

Source: PubMed

Link: https://pubmed.ncbi.nlm.nih.gov/35877595/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&fc=20210216052009&ff=20220725194005&v=2.17.7

Manual Selection: true

Machine Learning Gaussian Naive Bayes Model: false

Abstract

Astrocyte activation is associated with progressive inflammatory demyelination in multiple sclerosis (MS). The molecular mechanisms underlying astrocyte activation remain incompletely understood. Recent studies have suggested that classical neurotransmitter receptors are implicated in the modulation of brain innate immunity. We investigated the role of dopamine signaling in the process of astrocyte activation. Here, we show the upregulation of dopamine D2 receptor (DRD2) in reactive astrocytes…

Noun Phrases in Title

  • Inhibition
  • astrocytic DRD2 suppresses
  • CNS inflammation
  • an animal model
  • multiple sclerosis
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