1 min read

ID: 7714

Discovery Date: 02 March 2022, 11:33:15 UTC

Published Date: 2022-03-02 00:00:00

Source: BioMedCentral

Link: https://inflammregen.biomedcentral.com/articles/10.1186/s41232-022-00193-y

Manual Selection: true

Machine Learning Gaussian Naive Bayes Model: true

Abstract

AbstractGlial cells play crucial roles in brain homeostasis and pathogenesis of central nervous system (CNS) injuries and diseases. However, the roles of these cells and the molecular mechanisms toward regeneration in the CNS have not been fully understood, especially the capacity of them toward demyelinating diseases. Therefore, there are still very limited therapeutic strategies to restore the function of adult CNS in diseases such as multiple sclerosis (MS). Remyelination, a spontaneous regeneration process in the CNS, requires the involvement of multiple cellular and extracellular components. Promoting remyelination by therapeutic interventions is a promising novel approach to restore the CNS function. Herein, we review the role of glial cells in CNS diseases and injuries. Particularly, we discuss the roles of glia and their functional interactions and regulatory mechanisms in remyelination, as well as the current therapeutic strategies for MS.

Noun Phrases in Title

  • Central nervous system regeneration
  • the roles
  • glial cells
  • the potential molecular mechanism
  • remyelination
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