1 min read

ID: 811036

Short Link: https://gregory-ms.com/articles/811036/

Discovery Date: 06 August 2022, 13:05:11 UTC

Published Date: 2022-08-05 10:00:00

Source: PubMed

Link: https://pubmed.ncbi.nlm.nih.gov/35931213/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&fc=20210216052009&ff=20220806090507&v=2.17.7

Manual Selection: none

Machine Learning Gaussian Naive Bayes Model: false


Tuberous sclerosis complex (TSC) is a genetic disorder involving a variety of physical manifestations, and is associated with epilepsy and multiple serious neuropsychiatric symptoms. These symptoms are collectively known as TSC-associated neuropsychiatric disorders (TAND), which is a severe burden for patients and their families. Overactivation of the mechanistic target of rapamycin complex 1 (mTORC1) by mutations in TSC1 or TSC2 is thought to cause TSC, and mTORC1 inhibitors such as sirolimus…

Noun Phrases in Title

  • Sirolimus
  • seizures
  • neuropsychiatric symptoms
  • changes
  • microglial polarity
  • tuberous sclerosis complex model mice
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