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Preventive exercise attenuates IL-2-driven mood disorders in multiple sclerosis

CONCLUSIONS: Our results indicate an immunomodulatory effect of exercise in MS patients, associated with reduced CSF expression of IL-2, which might result in reduced mood disorders. These data suggest that exercise in the early …
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Looking Beyond Physical Disability: Cognitive Impairment in Persons With Multiple Sclerosis

CONCLUSIONS: In this project, less than half of eligible patients received cognitive screening after an extensive education program. Thus, education alone was not sufficient to change behavior. Other strategies to influence change …
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Treatment with Herbal Formula Extract in the hSOD1<sup>G93A</sup> Mouse Model Attenuates Muscle and Spinal Cord Dysfunction via Anti-Inflammation

Amyotrophic lateral sclerosis (ALS), a multicomplex neurodegenerative disease, has multiple underlying pathological factors and can induce other neuromuscular diseases, leading to muscle atrophy and respiratory failure. Currently, …
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Genetically modified macrophages accelerate myelin repair

Preventing neurodegeneration-associated disability progression in patients with multiple sclerosis (MS) remains an unmet therapeutic need. As remyelination prevents axonal degeneration, promoting this process in patients might …
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Cannabinoid Effect and Safety in Spasticity Following Stroke: A Double-Blind Randomized Placebo-Controlled Study

CONCLUSION: This study suggests that nabiximols use is probably safe in stroke patients, therefore cannabinoid usefulness may be further investigated. The lack of nabiximols effect could be related to low pain levels in recruited …
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Use of natalizumab in persons with multiple sclerosis: 2022 update

CONCLUSIONS: The recommendations of clinical neurologists seek to optimize the management of PwMS who may benefit from treatment with natalizumab.
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Recent insights into astrocytes as therapeutic targets for demyelinating diseases

Astrocytes are a group of glial cells that exhibit great morphological, transcriptional and functional diversity both in the resting brain and in response to injury. In recent years, astrocytes have attracted increasing interest …
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