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Distinct mechanisms of oligodendrocyte injury inform therapeutic interventions in multiple sclerosis

Brain. 2022 Nov 3:awac406. doi: 10.1093/brain/awac406. Online ahead of print. NO ABSTRACT PMID:36325693 | DOI:10.1093/brain/awac406
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Physical therapy and Telerehabilitation

The Effectiveness of anodal tDCS and cognitive training on cognitive functions in Multiple Sclerosis; A randomized, double-blind, parallel-group study

Background : Forty to 70% of patients with multiple sclerosis (MS) suffer from cognitive impairment during their illness. Only a few studies have examined the effects of anodal transcranial direct current stimulation (a-tDCS) …
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MS & Rel. Disorders auto manual

Cholesterol Pathway Biomarkers Are Associated with Neuropsychological Measures in Multiple Sclerosis

Highlights\n•\nCognitive impairment (CI) is frequent in persons with multiple sclerosis.\n•\nThe association of cholesterol pathways with cognitive impairment was investigated.\n•\nThe relative proportions of low density …
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Microglial/macrophage activation in the cerebrospinal fluid of neuromyelitis optica spectrum disorders

CONCLUSION: Our findings suggest that microglial/macrophage activation may be implicated in the pathogenesis of NMOSD.
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Diagnostic performance of artificial intelligence in multiple sclerosis: a systematic review and meta-analysis

CONCLUSION: Overall, AI models can further improve our diagnostic practice in MS patients. Our results indicate that the use of AI can aid the clinicians in accurate diagnosis of MS and improve current diagnostic approaches as …
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Metabolic Syndrome parameters and Multiple Sclerosis disease outcomes: a Portuguese cross-sectional study

Highlights\n\n- This study focuses on the evaluation of metabolic syndrome parameters.\n- The study includes adult patients with multiple sclerosis.\n- Waist Circumference correlates with lower cognitive function and increased …
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MS & Rel. Disorders auto

Cell-therapy procedure using anti-inflammatory macrophage M2 can potentially reduce Clinical Score in animals with Experimental Autoimmune Encephalomyelitis. A preclinical systematic review and meta-analysis study

CONCLUSIONS: Cell therapy procedure using MP2 can potentially alleviate the Clinical Scores Index and correct the motor defects in Recovery phase of EAE animals.
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Bruton's Tyrosine Kinase Inhibition in Multiple Sclerosis

PURPOSE OF REVIEW: Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) with a chronic and often progressive disease course. The current disease-modifying treatments (DMTs) limit disease …
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Bruton's Tyrosine Kinase Inhibitors: The Next Frontier of B-Cell-Targeted Therapies for Cancer, Autoimmune Disorders, and Multiple Sclerosis

Bruton’s tyrosine kinase (BTK) is an important protein belonging to the tyrosine kinase family that plays a key role in the intracellular signaling and proliferation, migration, and survival of normal and malignant B-lymphocytes …
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Isoflavone consumption reduces inflammation through modulation of phenylalanine and lipid metabolism

CONCLUSION: Isoflavone consumption alters the systemic metabolic landscape through concurrent increases in monounsaturated fatty acids and beneficial polyunsaturated fatty acids plus reduction in pro-inflammatory metabolites and …
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PubMed manual

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