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Development of clinical guidelines for service provision of functional electrical stimulation to support walking: mixed method exploration of stakeholder views

Background: Over the past 20 years Functional Electrical Stimulation (FES) has grown in clinical use to support walking in people with lower limb weakness or paralysis due to upper motor neuron lesions. Despite growing consensus …
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Do physical activity and social cognitive theory variable scores differ across symptom cluster severity groups in multiple sclerosis?

Disabil Health J. 2021 Jun 29:101163. doi: 10.1016/j.dhjo.2021.101163. Online ahead of print. ABSTRACT BACKGROUND: Persons with multiple sclerosis (MS) experience co-occurring symptoms termed "symptom clusters" that can be …
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Exercise as a multi-modal disease-modifying medicine in systemic sclerosis: An introduction by The Global Fellowship on Rehabilitation and Exercise in Systemic Sclerosis (G-FoRSS)

Best Pract Res Clin Rheumatol. 2021 Jun 30:101695. doi: 10.1016/j.berh.2021.101695. Online ahead of print. ABSTRACT Systemic sclerosis (SSc) is a heterogeneous multisystem autoimmune disease whereby its main pathological drivers …
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Modifying Diet and Exercise in MS (MoDEMS): Study design and protocol for a telehealth weight loss intervention for adults with obesity & Multiple Sclerosis

Contemp Clin Trials. 2021 Jun 30:106495. doi: 10.1016/j.cct.2021.106495. Online ahead of print. ABSTRACT Weight loss improves overall health, and reduces inflammation, risk of stroke, heart attack, diabetes, certain cancers, and …
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Spinal fluid myeloid microvesicles predict disease course in multiple sclerosis

Ann Neurol. 2021 Jul 3. doi: 10.1002/ana.26154. Online ahead of print. ABSTRACT OBJECTIVE: In vivo measures of myeloid activity are promising biomarkers in Multiple Sclerosis. We previously demonstrated that CSF myeloid …
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Alterations in intermuscular coordination underlying isokinetic exercise after a stroke and their implications on neurorehabilitation

Background: Abnormal intermuscular coordination limits the motor capability of stroke-affected upper limbs. By evaluating the intermuscular coordination in the affected limb under various biomechanical task constraints, the impact …
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Curing Multiple Sclerosis: How to Know When We're There?

Ann Neurol. 2021 Jul 2. doi: 10.1002/ana.26155. Online ahead of print. NO ABSTRACT PMID:34216039 | DOI:10.1002/ana.26155
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Circulating levels of tight junction proteins in multiple sclerosis: association with inflammation and disease activity before and after disease modifying therapy

AbstractBackgroundTight junction proteins contribute to maintenance of epithelial and endothelial barriers such as the intestinal barrier and the blood brain barrier (BBB). Increased permeability of these barriers has been linked …
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Motor Cortical Activation Assessment in Progressive Multiple Sclerosis Patients Enrolled in Gait Rehabilitation: A Secondary Analysis of the RAGTIME Trial Assisted by Functional Near-Infrared Spectroscopy

Diagnostics (Basel). 2021 Jun 9;11(6):1068. doi: 10.3390/diagnostics11061068. ABSTRACT This study aimed to determine cortical activation responses to two different rehabilitative programs, as measured through functional …
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Innovative trial approaches in immune-mediated inflammatory diseases: current use and future potential

Background: Despite progress that has been made in the treatment of many immune-mediated inflammatory diseases (IMIDs), there remains a need for improved treatments. Randomised controlled trials (RCTs) provide the highest form of …
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