2 min read

ID: 1127431

Short Link: https://gregory-ms.com/articles/1127431/

Discovery Date: 07 December 2022, 13:24:56 UTC

Published Date: 2022-12-07 00:00:00

Source: BioMedCentral

Link: https://inflammregen.biomedcentral.com/articles/10.1186/s41232-022-00244-4

Manual Selection: true

Machine Learning Gaussian Naive Bayes Model: false

Abstract

jats:titleAbstract</jats:title>jats:sec jats:titleBackground</jats:title> jats:pAxons play an essential role in the connection of the nervous system with the rest of the body. Axon lesions often lead to permanent impairment of motor and cognitive functions and the interaction with the outside world. Studies focusing on axon regeneration have become a research field with considerable interest. The purpose of this study is to obtain an overall perspective of the research field of axonal regeneration and to assist the researchers and the funding agencies to better know the areas of greatest research opportunities.</jats:p> </jats:sec>jats:sec jats:titleMethods</jats:title> jats:pWe conducted a bibliometric analysis and Latent Dirichlet Allocation (LDA) analysis of the global literature on axon regeneration based on the Web of Science (WoS) over the recent 22 years, to address the research hotspots, publication trends, and understudied areas.</jats:p> </jats:sec>jats:sec jats:titleResults</jats:title> jats:pA total of 21,018 articles were included, which in the recent two decades has increased by 125%. Among the top 12 hotspots, the annual productions rapidly increased in some topics, including jats:italicaxonal regeneration signaling pathway</jats:italic>, jats:italicaxon guidance cues</jats:italic>, jats:italicneural circuits and functional recovery</jats:italic>, jats:italicnerve conduits</jats:italic>, and jats:italiccells transplant</jats:italic>. Comparatively, the number of studies on jats:italicaxon regeneration inhibitors</jats:italic> decreased. As for the topics focusing on jats:italicnerve graft and transplantation</jats:italic>, the annual number of papers tended to be relatively stable. Nevertheless, the underlying mechanisms of axon regrowth have not been completely uncovered. A lack of notable research on the epigenetic programs and noncoding RNAs regulation was observed. The significance of cell-type-specific data has been highlighted but with limited research working on that. Functional recovery from neuropathies also needs further studies.</jats:p> </jats:sec>jats:sec jats:titleConclusion</jats:title> jats:pThe last two decades witnessed tremendous progress in the field of axon regeneration. There are still a lot of challenges to be tackled in translating these technologies into clinical practice.</jats:p> </jats:sec>

Noun Phrases in Title

  • Research hotspots
  • trends
  • axon regeneration
  • a bibliometric study
  • systematic review
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