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Association of Pain with Plasma C5a in Patients with Neuromyelitis Optica Spectrum Disorders During Remission

CONCLUSION: NMOSD patients during remission had elevated C5a and related inflammatory cytokines levels in peripheral blood. Elevated C5a may have a unique role in the pathogenesis of pain in NMOSD patients.
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PubMed auto

The role of basket trials in drug development for neurodegenerative disorders

CONCLUSIONS: Basket trials may increase drug development efficiency by reducing redundancy in trial implementation, enhancing recruitment, sharing placebo groups, and using biomarkers relevant to the mechanism of action of the …
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PubMed auto

Evolution of teriflunomide use in multiple sclerosis: A real-world experience

CONCLUSIONS: Our study confirms a major evolution in teriflunomide use in clinical settings, particularly for naïve patients and young women.
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PubMed auto

Patients with multiple sclerosis: a burden and cost of illness study

CONCLUSIONS: This study confirmed that MS carries a substantial burden to patients and society, highlighting the need for awareness of this disease.
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PubMed auto

Associations between diet quality and depression, anxiety, and fatigue in multiple sclerosis.

AbstractBackgroundMany people with multiple sclerosis (MS) modify their dietary intake post diagnosis, but there is little evidence that dietary modifications influence MS outcomes. MethodsPeople with a first clinical diagnosis of …
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MS & Rel. Disorders auto

Has the pandemic changed treatment strategy in multiple sclerosis?

AbstractBackground: Social distancing measures during the Covid-19 pandemic reduced access to health care and concerns were raised over the safety of immunosuppressive disease modifying treatments (DMT) for multiple sclerosis …
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MS & Rel. Disorders auto

Predictive value of number and volume of demyelinating plaques in treatment response in patients with multiple sclerosis treated with INF-B

CONCLUSION: The results of this study showed that imaging criteria provide a more objective tool for evaluating the effectiveness of treatment. These findings indicate that the number and volume of plaques could be two reliable …
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PubMed auto

The analysis of dynamic gene expression patterns in peripheral blood of multiple sclerosis patients indicates possible diagnostic and prognostic biomarkers

CONCLUSION: This study exhibits dynamic gene expression patterns that represent the significance of specified genes that are prospective diagnostic and prognostic biomarkers for multiple sclerosis.
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PubMed auto

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