Daily information on Multiple Sclerosis

Last Update 21 Oct, 09:30 with 5135 articles, since February 2021.

How it works

Step 1 Search for Multiple Sclerosis

Gregory searches the web multiple times a day looking for Articles and Clinical Trials.

Step 2 Index and organise

We use text analysis and machine learning to identify relevant articles to list on the home page.

Step 3 Filter and distribute

Every 2 days the admin team tags which articles show promise for new treatment and better quality of life for people with Multiple Sclerosis.

Every week the articles tagged as relevant for patients are compiled and sent to a mailing list of doctors, researchers, and physical therapists.

Latest relevant articles

indicates sources human selection indicates automatic selection

A novel method for maintaining the stability of freshly cultured Mesenchymal stem cells in clinical grade injection ready state without cryopreservation

Mesenchymal Stem Cells (MSCs) are multipotent cells with low immuonogenecity, and dynamic tissue repair potential, which explains the overwhelming attention they have attracted in regenerative therapy. One not…
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BioMedCentral human

Exosomes derived from bone marrow mesenchymal stromal cells promote remyelination and reduce neuroinflammation in the demyelinating central nervous system

Exp Neurol. 2021 Oct 12:113895. doi: 10.1016/j.expneurol.2021.113895. Online ahead of print. ABSTRACT Injury of oligodendrocytes (OLs) induces demyelination, and patients with neurodegenerative diseases exhibit demyelination …
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pubmed human

Effects of Mesenchymal Stem Cell-Derived Exosomes on Autoimmune Diseases

Front Immunol. 2021 Sep 27;12:749192. doi: 10.3389/fimmu.2021.749192. eCollection 2021. ABSTRACT Recent years, the immunosuppressive properties of mesenchymal stem cells (MSCs) have been demonstrated in preclinical studies and …
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pubmed human

Real-world application of autologous hematopoietic stem cell transplantation in 507 patients with multiple sclerosis

J Neurol. 2021 Oct 11. doi: 10.1007/s00415-021-10820-2. Online ahead of print. ABSTRACT OBJECTIVE: To investigate the results of real-world application of non-myeloablative autologous HSCT for multiple sclerosis (MS). METHODS: …
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pubmed auto

Blocking Kallikrein 6 promotes developmental myelination

Glia. 2021 Oct 9. doi: 10.1002/glia.24100. Online ahead of print. ABSTRACT Kallikrein related peptidase 6 (Klk6) is a secreted serine protease highly expressed in oligodendrocytes and implicated in demyelinating conditions. To …
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pubmed auto

Tofacitinib enhances remyelination and improves myelin integrity in cuprizone-induced mice

Immunopharmacol Immunotoxicol. 2021 Oct 7:1-9. doi: 10.1080/08923973.2021.1986063. Online ahead of print. ABSTRACT AIM: Demyelination and subsequent remyelination are well-known mechanisms in multiple sclerosis (MS) pathology. …
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pubmed auto

Nobiletin suppresses the development of experimental autoimmune encephalomyelitis mediated by modulation of T helper 17 cell differentiation

J Clin Biochem Nutr. 2021 Sep;69(2):145-150. doi: 10.3164/jcbn.20-178. Epub 2021 Mar 25. ABSTRACT Multiple sclerosis is an organ-specific autoimmune disease that targets the myelin antigen in the central nervous system. Nobiletin …
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pubmed auto

Spinal Cord Injury Induces Permanent Reprogramming of Microglia into a Disease-Associated State Which Contributes to Functional Recovery

Microglia are resident myeloid cells of the CNS. Recently, single-cell RNA sequencing (scRNAseq) has enabled description of a disease-associated microglia (DAM) with a role in neurodegeneration and demyelination. In this study, we …
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JNeuroSci auto

Diosgenin ameliorates cellular and molecular changes in multiple sclerosis in C57BL/6 mice

AbstractMultiple sclerosis (MS) is especially known as a demyelinating disease of the central nervous system. Current treatments for MS are mostly based on controlling neuroinflammation and there are no treatments to promote the …
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MS & Rel. Disorders auto

Astrocytic YAP prevents the demyelination through promoting expression of cholesterol synthesis genes in experimental autoimmune encephalomyelitis

Cell Death Dis. 2021 Oct 5;12(10):907. doi: 10.1038/s41419-021-04203-8. ABSTRACT Cholesterols are the main components of myelin, and are mainly synthesized in astrocytes and transported to oligodendrocytes and neurons in the adult …
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pubmed auto

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