Gregory MS
I am a robot that indexes and identifies relevant research and clinical trials for Multiple Sclerosis
@GregoryMS_ RSSDaily information on Multiple Sclerosis
Last Update 21 Oct, 09:30 with 5135 articles, since February 2021.
How it works
Step 1 Search for Multiple Sclerosis
Gregory searches the web multiple times a day looking for Articles and Clinical Trials.
Step 2 Index and organise
We use text analysis and machine learning to identify relevant articles to list on the home page.
Step 3 Filter and distribute
Every 2 days the admin team tags which articles show promise for new treatment and better quality of life for people with Multiple Sclerosis.
Every week the articles tagged as relevant for patients are compiled and sent to a mailing list of doctors, researchers, and physical therapists.
Latest relevant articles
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A novel method for maintaining the stability of freshly cultured Mesenchymal stem cells in clinical grade injection ready state without cryopreservation
Mesenchymal Stem Cells (MSCs) are multipotent cells with low immuonogenecity, and dynamic tissue repair potential, which explains the overwhelming attention they have attracted in regenerative therapy. One not…
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Exosomes derived from bone marrow mesenchymal stromal cells promote remyelination and reduce neuroinflammation in the demyelinating central nervous system
Exp Neurol. 2021 Oct 12:113895. doi: 10.1016/j.expneurol.2021.113895. Online ahead of print.
ABSTRACT
Injury of oligodendrocytes (OLs) induces demyelination, and patients with neurodegenerative diseases exhibit demyelination …
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Effects of Mesenchymal Stem Cell-Derived Exosomes on Autoimmune Diseases
Front Immunol. 2021 Sep 27;12:749192. doi: 10.3389/fimmu.2021.749192. eCollection 2021.
ABSTRACT
Recent years, the immunosuppressive properties of mesenchymal stem cells (MSCs) have been demonstrated in preclinical studies and …
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Real-world application of autologous hematopoietic stem cell transplantation in 507 patients with multiple sclerosis
J Neurol. 2021 Oct 11. doi: 10.1007/s00415-021-10820-2. Online ahead of print.
ABSTRACT
OBJECTIVE: To investigate the results of real-world application of non-myeloablative autologous HSCT for multiple sclerosis (MS).
METHODS: …
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Blocking Kallikrein 6 promotes developmental myelination
Glia. 2021 Oct 9. doi: 10.1002/glia.24100. Online ahead of print.
ABSTRACT
Kallikrein related peptidase 6 (Klk6) is a secreted serine protease highly expressed in oligodendrocytes and implicated in demyelinating conditions. To …
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Tofacitinib enhances remyelination and improves myelin integrity in cuprizone-induced mice
Immunopharmacol Immunotoxicol. 2021 Oct 7:1-9. doi: 10.1080/08923973.2021.1986063. Online ahead of print.
ABSTRACT
AIM: Demyelination and subsequent remyelination are well-known mechanisms in multiple sclerosis (MS) pathology. …
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Nobiletin suppresses the development of experimental autoimmune encephalomyelitis mediated by modulation of T helper 17 cell differentiation
J Clin Biochem Nutr. 2021 Sep;69(2):145-150. doi: 10.3164/jcbn.20-178. Epub 2021 Mar 25.
ABSTRACT
Multiple sclerosis is an organ-specific autoimmune disease that targets the myelin antigen in the central nervous system. Nobiletin …
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Spinal Cord Injury Induces Permanent Reprogramming of Microglia into a Disease-Associated State Which Contributes to Functional Recovery
Microglia are resident myeloid cells of the CNS. Recently, single-cell RNA sequencing (scRNAseq) has enabled description of a disease-associated microglia (DAM) with a role in neurodegeneration and demyelination. In this study, we …
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Diosgenin ameliorates cellular and molecular changes in multiple sclerosis in C57BL/6 mice
AbstractMultiple sclerosis (MS) is especially known as a demyelinating disease of the central nervous system. Current treatments for MS are mostly based on controlling neuroinflammation and there are no treatments to promote the …
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Astrocytic YAP prevents the demyelination through promoting expression of cholesterol synthesis genes in experimental autoimmune encephalomyelitis
Cell Death Dis. 2021 Oct 5;12(10):907. doi: 10.1038/s41419-021-04203-8.
ABSTRACT
Cholesterols are the main components of myelin, and are mainly synthesized in astrocytes and transported to oligodendrocytes and neurons in the adult …
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