2 min read

ID: 1159830

Short Link: https://gregory-ms.com/articles/1159830/

Discovery Date: 30 December 2022, 17:30:37 UTC

Published Date: 2022-12-30 00:00:00

Source: BioMedCentral

Link: https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-022-03825-5

Manual Selection: true

Machine Learning Gaussian Naive Bayes Model: false


jats:titleAbstract</jats:title>jats:sec jats:titleBackground</jats:title> jats:pjats:italicCurcuma longa</jats:italic> has been used as spices, food preservative, coloring material, and traditional medicine. This plant also has long been used for a variety of diseases including dyslipidemia, stomach disorders, arthritis, and hepatic diseases. The aim of the present investigation was to examine the anti-neuroinflammatory effects of the 50% ethanolic extract of jats:italicC. longa</jats:italic> in lipopolysaccharide (LPS)-induced BV2 microglial cells.</jats:p> </jats:sec>jats:sec jats:titleMethods</jats:title> jats:pGriess reaction was employed to measure the production of nitric oxide (NO), and the levels of prostaglandin E2 (PGEjats:sub2</jats:sub>) and pro-inflammatory cytokines such as interleukin 1-beta (IL-1β), IL-6 and tumor necrosis factor-α (TNF-α) were determined by using profit ELISA kits. Western blotting was used to determine the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), nuclear factor kappa B (NF-κB), mitogen activated protein kinases (MAPKs), heme oxygenase-1 (HO-1) and nuclear factor erythroid-2-related factor 2 (Nrf2).</jats:p> </jats:sec>jats:sec jats:titleResults</jats:title> jats:pPre-treatment with CLE inhibited the overproduction and overexpression of pro-inflammatory mediators including NO, PGEjats:sub2</jats:sub>, iNOS, COX-2, and pro-inflammatory cytokines such as IL-1β, IL-6 and TNF-α in LPS-induced BV2 cells. In addition, CLE suppressed the activation of the NF-κB and three MAPK signaling pathways. Treatment with CLE induced HO-1 protein expression by activating Nrf2 pathway, and inhibiting the HO-1 expression reversed the anti-inflammatory effect of CLE.</jats:p> </jats:sec>jats:sec jats:titleConclusion</jats:title> jats:pCLE showed anti-neuroinflammatory effects against LPS-induced microglial cells activation through the inhibition of production and expression of pro-inflammatory mediators by negative regulation of the NF-κB and MAPK signaling pathways. These anti-neuroinflammatory effects of CLE were mediated by HO-1/Nrf2 signaling pathway. Taken together, the present study suggests a potent effect of CLE to prevent neuroinflammatory diseases. It is necessary to perform additional efficacy evaluation through in vivo experiments.</jats:p> </jats:sec>

Noun Phrases in Title

  • The ethanolic extract
  • Curcuma longa
  • Korea
  • anti-neuroinflammatory effects
  • nuclear transcription factor
  • erythroid-2-related factor
  • 2/heme oxygenase-1
  • pathway
This is an independent project that runs on the good will of volunteers

You can help by spreading the word or by donating what you can to pay for the server costs.