1 min read

ID: 71

Short Link: https://gregory-ms.com/articles/71/

Discovery Date: 24 February 2021, 11:11:00 UTC

Published Date: 2021-02-24 00:00:00

Source: PubMed

Link: https://pubmed.ncbi.nlm.nih.gov/33622131/?fc=20210216052009&ff=20210224100934&v=2.1

Manual Selection: none

Machine Learning Gaussian Naive Bayes Model: false

Abstract

Proc Biol Sci. 2021 Feb 24;288(1945):20202793. doi: 10.1098/rspb.2020.2793. Epub 2021 Feb 24.

ABSTRACT

Neuroinflammation plays a crucial role during ageing and various neurological conditions, including Alzheimer's disease, multiple sclerosis and infection. Technical limitations, however, have prevented an integrative analysis of how lymphocyte immune receptor repertoires and their accompanying transcriptional states change with age in the central nervous system. Here, we leveraged single-cell sequencing to simultaneously profile B cell receptor and T cell receptor repertoires and accompanying gene expression profiles in young and old mouse brains. We observed the presence of clonally expanded B and T cells in the central nervous system of aged male mice. Furthermore, many of these B cells were of the IgM and IgD isotypes, and had low levels of somatic hypermutation. Integrating gene expression information additionally revealed distinct transcriptional profiles of these clonally expanded lymphocytes. Our findings implicate that clonally related T and B cells in the CNS of elderly mice may contribute to neuroinflammation accompanying homeostatic ageing.

PMID:33622131 | DOI:10.1098/rspb.2020.2793

Noun Phrases in Title

  • Single-cell immune repertoire
  • transcriptome sequencing reveals
  • that
  • the aged central nervous system
  • mice
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